Runx3 knockouts and stomach cancer
β Scribed by Levanon, Ditsa; Brenner, Ori; Otto, Florian; Groner, Yoram
- Book ID
- 110033647
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 87 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1469-221X
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## Abstract Cumulative evidences show that Runtβrelated transcription factor 3 (RUNX3) has a tumor suppressive role in various cancers. In particular, RUNX3 appears to be an important component of the transforming growth factorβΞ² (TGFβΞ²)βinduced tumor suppression pathway. Contrary to reports on thi
## Abstract The reputation of RUNX3 as a strong candidate for a tumor suppressor originated from studies of gastric carcinogenesis and now extends to a variety of other human cancers. The RUNX3 transcription factor is a downstream effector of the TGFβΞ² superfamily signaling pathway and has a critic