## Abstract The determination of gene linkage in the laboratory mouse was approached through somatic cell techniques. Cells of an established line of Chinese hamster lung fibroblasts, E‐36, were fused with a population of mouse macrophages obtained from the AHe/J inbred strain. A total of 62 primar
Roots: Contributions of boris, ephrussi to the development of somatic cell genetics
✍ Scribed by Mary C. Weiss
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 630 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
is needed is direct genetic analysis of somatic cells? for the assumed functional equivalence of (nuclei of> irrcvcrsibly differentiated somatic cells, however plausible, is only an hypothesis. Crosses between such cells being impossible, only nuclear transplantation from one somatic cell to another, or grafting of fragments of cytoplasm, could provide the required information; such experiments however will have to await the development of adequate technical dcvices'. Boris Ephrussi, 1952 (see ref. 2)
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