Contribution of genetic polymorphisms of stromal cell–derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer

✍ Scribed by Ying-Hock Teng; Te-Hsiung Liu; Hsien-Chun Tseng; Tsung-Te Chung; Chia-Ming Yeh; Yu-Chiung Li; Yu-Hsiang Ou; Long-Yau Lin; Hsiu-Ting Tsai; Shun-Fa Yang

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 136 KB
• Volume: 31
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.21094

✦ Synopsis

Abstract

Background.

The aim of this study was to evaluate the relations of SDF‐1 and its receptor, CXCR4, gene variants on oral cancer risk.

Methods.

PCR‐RFLP was used to measure SDF‐1‐3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer.

Results.

After being adjusted for age, individuals with A/G heterozygotes of SDF‐1 had a higher risk of 1.86‐fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66‐fold to progress to stage III or IV.

Conclusions.

SDF‐1‐3′A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph‐node metastasis of oral cancer disease in Taiwanese. © 2009 Wiley Periodicals, Inc. Head Neck, 2009