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Roles of β-amyloid converting enzymes BACE-1 and BACE-2 in β-amyloid secretion

✍ Scribed by Espinoza, Daniel O.; Potempska, Anna; Merz, George; Mack, Katherine; Metha, Pankaj; Currie, Julia R.; Miller, David L.


Book ID
123567125
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
168 KB
Volume
21
Category
Article
ISSN
0197-4580

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## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre