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Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication

✍ Scribed by Danny G. Winder; P. Jeffrey Conn

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 826 KB
Volume: 46
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(19961015)46:2<131::aid-jnr1>3.0.co;2-i

No coin nor oath required. For personal study only.

✦ Synopsis

The amino acid glutamate plays a key role in brain function. One of the major roles of glutamate is to mediate fast excitatory neurotransmission via activation of ionotropic glutamate receptors (iGluRs). More recently, however, it has become clear that glutamate also serves a regulatory function through activation of receptors coupled to modulation of second messenger systems [metabotropic glutamate receptors (mGluRs)]. A body of evidence suggests that mGluRs regulate neuronal function through modulation of ion channels and enzymes to modulate cellular excitability and synaptic transmission. Interestingly, it has become clear that in addition to activation of neuronal receptors, glutamate can activate both iGluRs and mGluRs on glia. A growing body of evidence suggests that the mGluRs on glia play important roles in both glial function and mediation of intercellular signaling.

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