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Development and function of metabotropic glutamate receptors in cat visual cortex

✍ Scribed by Daw, Nigel W. ;Reid, Silvia N. M. ;Beaver, Christopher J.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 102 KB
Volume: 41
Category: Article
ISSN: 0022-3034
DOI: 10.1002/(sici)1097-4695(199910)41:1<102::aid-neu13>3.0.co;2-2

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✦ Synopsis

Metabotropic glutamate receptors have been implicated in plasticity in the hippocampus and cerebellum. Are they also involved in plasticity in the visual cortex? This is a complicated question because of the diversity of metabotropic glutamate receptors and the variations in both receptors and plasticity with layer. Inhibition driven by group II metabotropic glutamate receptors is certainly correlated with ocular dominance segregation in layer IV of the cortex. Of the group I metabotropic glutamate receptors, mGluR5 may be in-volved in plasticity, but mGluR1 is unlikely to be. Both group I and group II receptors produce increases in cyclic adenosine monophosphate which are clearly related to plasticity. Further conclusions await the development of agonists and antagonists specific for individual metabotropic glutamate receptors, as opposed to groups of the receptors.

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