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Roles of Different CYP Enzymes in the Formation of Specific Fluvastatin Metabolites by Human Liver Microsomes

โœ Scribed by Takaki Toda; Erik Eliasson; Birgitta Ask; Nobuo Inotsume; Anders Rane

Book ID
111316700
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
172 KB
Volume
105
Category
Article
ISSN
1742-7835

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โœ P. Bonnabry; T. Leemann; P. Dayer ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer ๐ŸŒ English โš– 447 KB

## Objective: The nature of the enzyme(s) catalysing the biotransformation of lornoxicam to one of its major metabolites, 5'-hydroxy-lornoxicam, has been investigated in human liver microsomes. the reaction kinetics were characterised, the affinity of lornoxicam for three major human drug metabolis