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Roles for the type III TGF-β receptor in human cancer

✍ Scribed by Catherine E. Gatza; Sun Young Oh; Gerard C. Blobe


Book ID
113528389
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
474 KB
Volume
22
Category
Article
ISSN
0898-6568

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Transforming growth factor-beta (TGF-beta) signaling is initiated following heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Both receptors are required for TGF-beta responsiveness. In the present study, we characterized the actions of TGF-b