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Roles for cytoplasmic polyadenylation in cell cycle regulation

✍ Scribed by Rebecca L. Read; Chris J. Norbury

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
188 KB
Volume
87
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Polyadenylation of eukaryotic mRNAs in the nucleus promotes their translation following export to the cytoplasm and is an important determinant of mRNA stability. An additional level of control of gene expression is provided by cytoplasmic polyadenylation, which activates translation of a number of mRNAs important in orchestrating cell cycle events in oocytes. Recent studies indicate that cytoplasmic polyadenylation may be a mechanism of translational activation that is more widespread in eukaryotic cells. Here we discuss the roles of a recently identified family of nucleotidyl transferases (encoded by the cid1 gene family) in cell cycle regulation. To date, this family has been characterised mainly in yeasts, but it is conserved throughout the eukaryotes. Biochemical studies have indicated that a subset of members of this family function as cytoplasmic poly(A) polymerases targeting specific mRNAs for translation. This form of translational control appears to be particularly important for cell cycle regulation following inhibition of DNA synthesis. J. Cell. Biochem. 87: 258–265, 2002. Β© 2002 Wiley‐Liss, Inc.

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