In most species, transcription is essentially silent during the first mitotic cell cycles that follow fertilization. This means that the regulation of gene expression in early embryos heavily relies on the translational activation or inactivation of maternal mRNAs. In mammals, the mechanisms that co
Unmasking the role of the 3′ UTR in the cytoplasmic polyadenylation and translational regulation of maternal mRNAs
✍ Scribed by Michael Wormington
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 485 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
UTRs of certain CPE-containing mRNAs promote their deadenylation after fertilization, thereby restricting their translation to eggs(14). The characterization and purification of the factors that mediate these changes in polyadenylation are advancing rapidly( 17).
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