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Role of Zinc in the Structure and Toxic Activity of Botulinum Neurotoxin †

✍ Scribed by Fu, Fen-Ni; Lomneth, Richard B.; Cai, Shuowei; Singh, Bal Ram

Book ID
126406448
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
201 KB
Volume
37
Category
Article
ISSN
0006-2960

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Structure and enzymatic activity of botu
Structure and enzymatic activity of botulinum neurotoxins
✍ Subramanyam Swaminathan; Subramanian Eswaramoorthy; Desigan Kumaran 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB

The structure of botulinum neurotoxin type B (BoNT/B) is analyzed, and it is demonstrated that the carbonyl oxygen of the scissile bond comes close to the zinc ion to form a Michaelis complex. The hydrated carbonyl is activated by the nucleophilic water, which moves closer to Glu 230 to form hydroge