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Role of Zinc Binding in Type A Botulinum Neurotoxin Light Chain's Toxic Structure †

✍ Scribed by Li, ; Singh, Bal Ram

Book ID
125930979
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
68 KB
Volume
39
Category
Article
ISSN
0006-2960

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The secondary and tertiary structural features of botulinum neurotoxin (NT) serotype A, a dichain protein (Mr 145,000), and its two subunits, the heavy (H) and light (L) chains (Mr 97,000 and 53,000, respectively) were examined using circular dichroism and fluorescence spectorscopy. Nearly 70% of th