𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Crystal structure of botulinum neurotoxin type A and implications for toxicity

✍ Scribed by Lacy, D. Borden; Tepp, William; Cohen, Alona C.; DasGupta, Bibhuti R.; Stevens, Raymond C.

Book ID
109679551
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
588 KB
Volume
5
Category
Article
ISSN
1072-8368

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Molecular topography and secondary struc
Molecular topography and secondary structure comparisons of botulinum neurotoxin types A, B and E
✍ Bal Ram Singh; B. R. DasGupta πŸ“‚ Article πŸ“… 1989 πŸ› Springer 🌐 English βš– 650 KB

Botulinum neurotoxin (NT) serotypes A, B and E differ in microstructure and biological activities. The three NTs were examined for secondary structure parameters (alpha-helix, beta-sheet, beta-turn and random coil content) on the basis of circular dichroism; degree of exposed Tyr residues (second de

Pharmacokinetic properties of different
Pharmacokinetic properties of different formulations of botulinum neurotoxin type A
✍ Kai Wohlfarth; Knut Kampe; Hans Bigalke πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 45 KB

Although the relative potency measured by the number of units per nanogram of the toxin is different for the three preparations (BOTOX Ο­ 20 U/ng; Dysport Ο­ 40 U/ng, and CS-BOT Ο­ 15.2 U/ng), the effective dose for CS-BOT is similar to that of BOTOX (Allergan, Irvine, CA). Despite the twofold differen

Reductive methylation of lysine residues
Reductive methylation of lysine residues of botulinum neurotoxin types A and B
✍ Venugopal Sathyamoorthy; Bibhuti R. DasGupta πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 571 KB

Reductive methylation of botulinum neurotoxin (NT) serotypes A and B at various ratios of protein to reagent modified up to 75% of the lysine residues. Amino acid analysis of the modified proteins (HCl hydrolysed) confirmed selective modifications of lysine. The derivative N,N-dimethyl lysine was mo