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Role of zetaPKC in B-cell signaling and function

✍ Scribed by Martin, P.


Book ID
111749623
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
308 KB
Volume
21
Category
Article
ISSN
0261-4189

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Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal