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Role of Syk in B-cell development and antigen-receptor signaling

✍ Scribed by Cornall, R. J.; Cheng, A. M.; Pawson, T.; Goodnow, C. C.

Book ID: 121742700
Publisher: National Academy of Sciences
Year: 2000
Tongue: English
Weight: 209 KB
Volume: 97
Category: Article
ISSN: 0027-8424
DOI: 10.1073/pnas.97.4.1713

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Recent gene-targeting experiments have highlighted the importance of the intracellular protein tyrosine kinases Lyn, Syk, and Btk in BCR signal transduction and B cell development. In addition, the interactions of these kinases and their regulatory mechanisms have been reported. Activation loop phos