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Role of Btk in B cell development and signaling

โœ Scribed by Stephen Desiderio

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
669 KB
Volume
9
Category
Article
ISSN
0952-7915

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โœฆ Synopsis

Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.

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