๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Notch signaling in T- and B-cell development

โœ Scribed by Freddy Radtke; Anne Wilson; H Robson MacDonald

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
140 KB
Volume
16
Category
Article
ISSN
0952-7915

No coin nor oath required. For personal study only.

โœฆ Synopsis

The Notch family of evolutionarily conserved proteins regulates a broad spectrum of cell-fate decisions and differentiation processes during fetal and post-natal development. The best characterized role of Notch signaling during mammalian hematopoiesis and lymphopoiesis is the essential function of the Notch1 receptor in T-cell lineage commitment. More recent studies have addressed the roles of other Notch receptors and ligands, as well as their downstream targets, revealing additional novel functions of Notch signaling in intra-thymic T-cell development, B-cell development and peripheral T-cell function.

๐Ÿ“œ SIMILAR VOLUMES

Notch signaling in T cell development
Notch signaling in T cell development
โœ Michael L Deftos; Michael J Bevan ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 104 KB

cell lineage and may function together with signals from the pre-TCR and the TCR to regulate subsequent steps of T cell development.

Linking Notch signaling, chromatin remod
Linking Notch signaling, chromatin remodeling, and T-cell leukemogenesis
โœ Emery H. Bresnick; Jianlin Chu; Heather M. Christensen; Bernice Lin; Jason Norto ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 266 KB

Intercellular communication that controls the developmental fate of multipotent cells is commonly mediated by the Notch family of transmembrane receptors. Speciยฎc transmembrane ligands activate Notch receptors on neighboring cells inducing the proteolytic liberation and nuclear translocation of the

B-Raf-mediated signaling pathway regulat
B-Raf-mediated signaling pathway regulates T cell development
โœ Hirotake Tsukamoto; Atsushi Irie; Satoru Senju; Antonisโ€„K. Hatzopoulos; Leszek W ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 379 KB

## Abstract The activities of the Raf kinase family proteins control extracellular signalโ€regulated kinase (ERK) activation in many aspects of cellular responses. However, the relative contributions of individual isozymes to cellular functions including T cell responses are still unclear. In additi