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Role of uridine phosphorylase in the anabolism of 5-fluorouracil

✍ Scribed by Pauline M. Schwartz; Robyn D. Moir; Carolyn M. Hyde; Paul J. Turek; Robert E. Handschumacher

Book ID
115778614
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
474 KB
Volume
34
Category
Article
ISSN
0006-2952

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19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine
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## Abstract A uridine phosphorylase inhibitor, 5‐benzylacyclouridine (BAU), has been utilized as biochemical modulator of 5‐fluorouracil (5‐FU) anti‐tumor activity in a murine tumor model. The effect of BAU on 5‐FU metabolism has been evaluated using __in vitro__ and __in vivo__ ^19^F NMR spectrosc