Synthesis and interaction with uridine phosphorylase of 5'-deoxy-4',5-difluorouridine, a new prodrug of 5-fluorouracil
โ Scribed by Ajmera, Sudhir; Bapat, Ashok R.; Danenberg, Peter V.; Stephanian, Edic
- Book ID
- 120980874
- Publisher
- American Chemical Society
- Year
- 1988
- Tongue
- English
- Weight
- 718 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
Cycloaddition of diazomethane with 3'-deoxy-3'-methylene-and 4',S-didehydro-5'-deoxynucleoside derivative8 followed by sensitized photochemical extrusion of nitrogen provided the previously unreported 3'-and 4'-spirocyclopropane nucleoside derivatives. Enhancement of the cycloaddition reactions by e
1 3.11.96) 2'-Deoxy-5-(isothiazol-5-yl)uridine (12) was synthesized starting from 2'-deoxy-5-iodouridine using a Pdcatalysed cross-coupling reaction with propiolaldehyde diethyl acetal followed by deprotection and ring closure using thiosulfate. 2'-Deoxyuridine 12 has a particular place among the 5-