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High-performance liquid chromatographic determination of 5-fluorouracil and its prodrugs, tegafur and 4-deoxy-5-fluorouracil, in rat plasma

✍ Scribed by Venkateswar R. Jarugula; F. Douglas Boudinot

Publisher
Elsevier Science
Year
1996
Weight
300 KB
Volume
677
Category
Article
ISSN
0378-4347

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## Abstract On‐line determination of the anti‐tumor drug 5‐fluorouracil (5‐FU) and its prodrug, tegafur (TF) was achieved for the first time by capillary electrophoresis with large‐volume sample stacking (CE–LVSS). The optimal electrophoretic buffer consisted of 30 mM phosphate buffer at pH 8.0. Wi