✦ LIBER ✦

Role of type 1 and type 2 T helper cells in allergic diseases

✍ Scribed by Martien L. Kapsenberg; Henk M. Jansen; Jan D. Bos; Eddy A. Wierenga

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 808 KB
Volume: 4
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(92)90063-k

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✦ Synopsis

Various characteristics of atopic allergic disorders seem to be causally related with the activation of allergen-specific T helper lymphocytes with a type 2 cytokine secretion profile, including high levels of interleukin-4 and interleukin-5. These cytokines are responsible for the occurrence of elevated levels of serum allergen-specific IgE and eosinophilia and play an important role in local inflammatory reactions.

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