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Antagonizing the differentiation and functions of human T helper type 2 cells

✍ Scribed by Jan E de Vries; JoséM Carballido; Thierry Sornasse; Hans Yssel

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
827 KB
Volume
7
Category
Article
ISSN
0952-7915

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✦ Synopsis

Allergen-specific T cells from atopic patients generally belong to the T-helper type 2 subset. IL-4 and IL-13 produced by these cells induce IgE synthesis by B cells and play a major role in allergic disease mediated by IgE. Recent advances in our understanding of the differentiation and IgE-inducing activities of T-helper type 2 cells suggest that targeting allergen-specific T cells may provide a novel way to intervene in allergy.

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