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Induction of non-responsiveness in human allergen-specific type 2 T helper cells

✍ Scribed by Hans Yssel; Stephan Fasler; Jonathan Lamb; Jan E. de Vries


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
764 KB
Volume
6
Category
Article
ISSN
0952-7915

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Allergen-specific T cells from atopic patients generally belong to the T-helper type 2 subset. IL-4 and IL-13 produced by these cells induce IgE synthesis by B cells and play a major role in allergic disease mediated by IgE. Recent advances in our understanding of the differentiation and IgE-inducin