Regulation of ST2L expression on T helper (Th) type 2 cells
✍ Scribed by Robert W. Carter; Matthew J. Sweet; Damo Xu; Roman Klemenz; Foo Y. Liew; Woon Ling Chan
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 122 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The T1/ST2 gene encodes, as a result of differential splicing, a cell surface protein (transmembrane form of T1/ST2, ST2L) and a soluble, secreted, protein (ST2). Here, we show that transcripts for both ST2L and ST2 are present in activated human Th2 clones, but not in Th1 and T regulatory clones. T
## BACKGROUND. T helper type 1 cells (Th1), Th2, T cytotoxic type 1 cells (Tc1), and Tc2 play important immunoregulatory roles. Some recent studies have demonstrated that an elevated level of type 2 cytokines, such as interleukin-10, contributes to the ability of cancer cells to escape immunosurvei