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Role of the p38 MAPK pathway in cisplatin-based therapy

✍ Scribed by Losa, Javier Hernández; Cobo, Carlos Parada; Viniegra, Juan Guinea; Lobo, Victor Javier Sánchez-Arevalo; Cajal, Santiago Ramón y; Sánchez-Prieto, Ricardo

Book ID
110067705
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
363 KB
Volume
22
Category
Article
ISSN
0950-9232

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## Abstract Activation of p38 MAPK is a critical requisite for the therapeutics activity of the antitumor agent cisplatin. In this sense, a growing body of evidences supports the role of c‐Abl as a major determinant of p38 MAPK activation, especially in response to genotoxic stress when triggered b