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Regulation of VEGF-induced endothelial cell PAF synthesis: role of p42/44 MAPK, p38 MAPK and PI3K pathways

✍ Scribed by Pascal N Bernatchez; Bruce G Allen; David S Gélinas; Gaétan Guillemette; Martin G Sirois


Book ID
110005971
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
265 KB
Volume
134
Category
Article
ISSN
0007-1188

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## Abstract Sphingosine 1‐phosphate (S1P) has been shown to regulate smooth muscle cell proliferation, migration, and vascular maturation. S1P increases the expression of several proteins including COX‐2 in vascular smooth muscle cells (VSMCs) and contributes to arteriosclerosis. However, the mecha