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Role of ring size on the secondary structure and antibiotic activity of gramicidin S

✍ Scribed by TAMAKI, MAKOTO ;ARAI, IZUMI ;AKABORI, SADATOSHI ;MURAMATSU, ICHIRO

Book ID
115099829
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
323 KB
Volume
45
Category
Article
ISSN
0367-8377

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📜 SIMILAR VOLUMES

Comparison of conformation and antimicro
Comparison of conformation and antimicrobial activity of synthetic analogs of gramicidin S: Stereochemical consideration of the role of D-phenylalanine in the antibiotic
✍ M. Kawai; U. Nagai 📂 Article 📅 1978 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 925 KB

## Abstract In order to study the role of D‐amino acid residues in keeping the stable β‐sheet conformation and in the antimicrobial activity of gramicidin S (GS), the four analogs of GS containing D‐Ala, L‐Ala, Gly, and Aib (α‐aminoisobutyric acid) in place of D‐Phe were synthesized. D‐Ala‐and Gly‐

Synthesis, biological activity and solut
Synthesis, biological activity and solution structure of new analogues of the antimicrobial Gramicidin S
✍ Elżbieta Kamysz; Beata Mickiewicz; Wojciech Kamysz; Sylwia Bielińska; Sylwia Rod 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 295 KB

## Abstract Gramicidin S (GS) is a cyclo‐decapeptide antibiotic isolated from __Bacillus brevis__. The structural studies have shown that GS forms a two‐stranded antiparallel β‐sheet imposed by two II′ β‐turns. Despite its wide Gram+ and Gram− antimicrobial spectrum, GS is useless in therapy becaus