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Role of retinoic acid in the modulation of benzo(a)pyrene-DNA adducts in human hepatoma cells: Implications for cancer prevention

✍ Scribed by Guo-Dong Zhou; Molly Richardson; Inayat S. Fazili; Jianbo Wang; Kirby C. Donnelly; Fen Wang; Brad Amendt; Bhagavatula Moorthy


Book ID
113924799
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
790 KB
Volume
249
Category
Article
ISSN
0041-008X

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DNA adducts are mainly detected by 32 P-postlabeling and enzyme-linked immunosorbent assays. We have established a method for detection of benzo[a]pyrene-diol-epoxide (BPDE)-DNA adducts by flow cytometry, and have clarified the effects of the DNA adducts on cell-cycle progression and the relationshi