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Role of protein kinase C in bradykinin-induced prostaglandin formation in osteoblasts

✍ Scribed by Östen Ljunggren; Bertil B. Fredholm; Christer Nordstedt; Sverker Ljunghall; Ulf H. Lerner


Book ID
113398446
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
653 KB
Volume
244
Category
Article
ISSN
0922-4106

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Protein kinase C activation amplifies pr
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In cloned osteoblast-like cells, MC3T3-EII prostaglandin F, , (PGF,,) stimulated arachidonic acid (AA) release in a dose-dependent manner in the range between 1 n M and 10 pM. 12-O-tetradecanoylphorbol-l3-acetate (TPA), a protein kinase C (PKC) activator, which by itself had little effect on AA rele