In cloned osteoblast-like cells, MC3T3-EII prostaglandin F, , (PGF,,) stimulated arachidonic acid (AA) release in a dose-dependent manner in the range between 1 n M and 10 pM. 12-O-tetradecanoylphorbol-l3-acetate (TPA), a protein kinase C (PKC) activator, which by itself had little effect on AA rele
Protein kinase C mediates flow-induced prostaglandin E2production in osteoblasts
✍ Scribed by Kathleen M. Reich; John A. Frangos
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 415 KB
- Volume
- 52
- Category
- Article
- ISSN
- 1432-0827
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Ghrelin, a newly identified gastric peptide, is known for its potent activity in growth hormone release and appetite. Our recent study showed that ghrelin could stimulate protein kinase C‐mediated activation of nuclear factor‐κB (NF‐κB) and interleukin‐8 secretion in human colonic epith
## Abstract Syndecans are proteoglycans that act as signaling molecules. Previously, we showed that syndecan‐2 (SYND2) is involved in the control of osteoblastic (OB) cell apoptosis. Here, we show a novel functional interaction between SYND2 and protein kinase C δ (PKCδ). Overexpression of SYND2 in
## Abstract We previously reported that prostaglandin F~2α~ (PGF~2α~) receptor is coupled to pertussis toxin (PTX)–sensitive GTP‐binding protein (G protein) in osteoblast‐like MC3T3‐E1 cells [Miwa et al. (1990): Biochem Biophys Res Commun 171:1229–1235]. In the present study, we examined the effect