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Role of pfmdr1 mutations on chloroquine resistance in Plasmodium falciparum isolates with pfcrt K76T from Papua New Guinea

✍ Scribed by Toshihiro Mita; Akira Kaneko; Francis Hombhanje; Ilomo Hwaihwanje; Nobuyuki Takahashi; Hikota Osawa; Takahiro Tsukahara; Andrew Masta; Jeffery K. Lum; Takatoshi Kobayakawa; Takashi Ishizaki; Anders Björkman


Book ID
116181835
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
152 KB
Volume
98
Category
Article
ISSN
0001-706X

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The development in Plasmodium falciparum of the resistance to chloroquine (CQ) constitutes a public health priority, due to its direct influence in childhood mortality. The molecular basis for CQ resistance (CQR) is still unclear but, recently, a new relevant gene, named pfcrt, with several point mu