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Chloroquine-resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the pfmdr1 gene thought to be associated with chloroquine resistance

✍ Scribed by F.M. Awad-El-Kariem; M.A. Miles; D.C. Warhurst


Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
811 KB
Volume
86
Category
Article
ISSN
0035-9203

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Mutations in the Plasmodium falciparum pfcrt gene on chromosome 7 and possibly mutations in pfmdr1 on chromosome 5 have a role in conferring resistance against chloroquine (CQ), as do mutations of pfdhfr on chromosome 4 and pfdhps on chromosome 8 in terms of resistance against sulfadoxine/pyrimetham