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Two mutations in the multidrug-resistance gene homologue of Plasmodium falciparum, pfmdr1, are not useful predictors of in-vivo or in-vitro chloroquine resistance in southern Africa

✍ Scribed by K.R.G. McCutcheon; J.A. Freese; J.A. Frean; B.L. Sharp; M.B. Markus


Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
478 KB
Volume
93
Category
Article
ISSN
0035-9203

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Relationship between the Pfcrt T76 and t
✍ Halidou Tinto; Jean Bosco OuΓ©draogo; Annette Erhart; Chantal Van Overmeir; Jean- πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 81 KB

The relationship between Pfcrt T76 and Pfmdr-1 Y86 mutations in Plasmodium falciparum was explored in samples from patients with uncomplicated malaria and tested in vitro and in vivo with chloroquine (CQ) in Burkina Faso. The two mutations were strongly related. The Pfcrt T76 mutation was found in 8