Chloroquine resistance of Plasmodium falciparum: further evidence for a lack of association with mutations of the pfmdr1 gene
β Scribed by Kosuke Haruki; Patrick G. Bray; Stephen A. Ward; Marcel Hommel; Graeme Y. Ritchie
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 148 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0035-9203
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To assess the level of resistance to chloroquine (CQ) of Plasmodium falciparum in The Gambia in 1995-1996 we measured susceptibility in vivo by quantifying parasitaemia of children with mild malaria on days 4 and 8 after treatment. Pretreatment blood samples were used for susceptibility testingin vi
Mutations in the Plasmodium falciparum pfcrt gene on chromosome 7 and possibly mutations in pfmdr1 on chromosome 5 have a role in conferring resistance against chloroquine (CQ), as do mutations of pfdhfr on chromosome 4 and pfdhps on chromosome 8 in terms of resistance against sulfadoxine/pyrimetham
Lambda red- gam- makes a small plaque on P2 lysogens (the partial Spi- phenotype). It has been proposed that inactivation of an additional gene delta, mapping in the recombination region, makes the plaque bigger (the full Spi- phenotype) (Zissler et al., 1917b). The present paper demonstrates that t