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Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFα expression in human fetal astrocytes

✍ Scribed by Liwei L. Hua; Meng-Liang Zhao; Melissa Cosenza; Mee-Ohk Kim; Huan Huang; Herbert B. Tanowitz; Celia F. Brosnan; Sunhee C. Lee

Book ID
114137609
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
413 KB
Volume
126
Category
Article
ISSN
0165-5728

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## Abstract Expression of inducible nitric oxide synthase (iNOS), which leads to the production of nitric oxide (NO), is stimulated by proinflammatory cytokines such as interleukin‐1β (IL‐1β) and tumor necrosis factor‐α (TNF‐α). Here we report on the roles of nuclear factor‐κB (NF‐κB) and mitogen‐a