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Methoxychlor-induced inducible nitric oxide synthase and proinflammatory cytokines expression in macrophages via NF-κB, ERK, and p38 mitogen-activated protein kinases

✍ Scribed by Ji Young Kim; Kyo Nyeo Oh; Eun Hee Han; Dong Hee Kim; Tae Cheon Jeong; Eung Seok Lee; Hye Gwang Jeong


Book ID
116290809
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
416 KB
Volume
333
Category
Article
ISSN
0006-291X

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## Abstract Expression of inducible nitric oxide synthase (iNOS), which leads to the production of nitric oxide (NO), is stimulated by proinflammatory cytokines such as interleukin‐1β (IL‐1β) and tumor necrosis factor‐α (TNF‐α). Here we report on the roles of nuclear factor‐κB (NF‐κB) and mitogen‐a