## Abstract Expression of inducible nitric oxide synthase (iNOS), which leads to the production of nitric oxide (NO), is stimulated by proinflammatory cytokines such as interleukin‐1β (IL‐1β) and tumor necrosis factor‐α (TNF‐α). Here we report on the roles of nuclear factor‐κB (NF‐κB) and mitogen‐a
Role of Mitogen-Activated Protein Kinase Cascades in Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide in a Rat Schwann Cell Line
✍ Scribed by Haibo Wang; Chun Cheng; Yongwei Qin; Shuqiong Niu; Shangfeng Gao; Xin Li; Tao Tao; Aiguo Shen
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 385 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0364-3190
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Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe
## Abstract Cytokine‐induced expression of inducible nitric oxide synthase (iNOS) and concomitant production of nitric oxide (NO) involve activation of mitogen‐activated protein (MAP) kinases and are in most cases mediated by the transcription factor NF‐κB. We investigated the role of p38 MAP kinas