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Role of microglia and host prion protein in neurotoxicity of a prion protein fragment

✍ Scribed by Brown, David R.; Schmidt, Bernhard; Kretzschmar, Hans A.

Book ID
109795515
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
709 KB
Volume
380
Category
Article
ISSN
0028-0836

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A synthetic peptide consisting of amino acid residues 106 to 126 of the human prion protein (PrP c ) that forms fibrils in vitro is toxic to cultured neurons. We have previously shown that the neurotoxic effect of this peptide is related to microglia activation (Brown et al., 1996a). For closer insi