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Hydrogen peroxide cleavage of the prion protein generates a fragment able to initiate polymerisation of full length prion protein

✍ Scribed by Salama R. Abdelraheim; Silvia Královicová; David R. Brown


Book ID
116307182
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
421 KB
Volume
38
Category
Article
ISSN
1357-2725

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✍ Luisa Ronga; Pasquale Palladino; Gabriella Saviano; Teodorico Tancredi; Ettore B 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB

## Abstract The 173–195 segment corresponding to the helix 2 of the globular PrP domain is a good candidate to be one of the several ‘spots’ of intrinsic structural flexibility, which might induce local destabilization and concur to protein transformation, leading to aggregation‐prone conformations