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Neurotoxicity of a prion protein fragment

โœ Scribed by Forloni, Gianluigi; Angeretti, Nadia; Chiesa, Roberto; Monzani, Enrico; Salmona, Mario; Bugiani, Orso; Tagliavini, Fabrizio

Book ID
109783820
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
664 KB
Volume
362
Category
Article
ISSN
0028-0836

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A peptide fragment of the prion protein, PrP106-126 is toxic to neuronal cells in culture. This toxicity is dependent on neuronal expression of the prion protein (PrP c ) and also the presence of microglia. The role of expression of the PrP c in neurotoxicity of this peptide was investigated using m