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Cytoplasmic prion protein induces forebrain neurotoxicity

โœ Scribed by Xinhe Wang; Stephanie L. Bowers; Fei Wang; Xin-an Pu; Randy J. Nelson; Jiyan Ma


Book ID
116270762
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
584 KB
Volume
1792
Category
Article
ISSN
0925-4439

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A peptide fragment of the prion protein, PrP106-126 is toxic to neuronal cells in culture. This toxicity is dependent on neuronal expression of the prion protein (PrP c ) and also the presence of microglia. The role of expression of the PrP c in neurotoxicity of this peptide was investigated using m