## Abstract Macrophages from the Lewis (Le) rat strain are significantly more cytotoxic to a Moloney sarcoma tumor, both __in vivo__ and __in vivo__, than are macrophages from the Brown Norway (BN) strain. Activity of macrophages from (Le Γ BN) F~1~ rats that are histocompatible with the Moloney sa
Role of Immunosurveillance against Chemically Induced Rat Tumors
β Scribed by R. W. Baldwin
- Book ID
- 111246669
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 664 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0105-2896
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D A rat sarcomas PI and P, were induced by dimethylbenz (a) anthracene. A tumor-specific immune response of D A rats against P,-turnor cells could be demonstrated at the humoral and cellular level. D A anti-PI antibodies were purified on fixed PI-tumor cells and used as auto- immunogen in D A rats f
A high frequency of point mutations at codon 12 of the Ki-ras gene has previously been reported for rat kidney mesenchymal tumors induced by methylating N-nitroso compounds. In this study, we analyzed renal tumors with divergent histogenesis, i.e., mesenchymal tumors (sarcomas), cortical epithelial