𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genetic role of rat macrophage cytotoxicity against tumor

✍ Scribed by Glenn A. Miller; Joseph D. Feldman

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
635 KB
Volume
18
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Macrophages from the Lewis (Le) rat strain are significantly more cytotoxic to a Moloney sarcoma tumor, both in vivo and in vivo, than are macrophages from the Brown Norway (BN) strain. Activity of macrophages from (Le Γ— BN) F~1~ rats that are histocompatible with the Moloney sarcoma tumor is directed toward tumor and/or virus‐associated antigens and is expressed as a dominant genetic trait. Experiments with backcross rats suggest that the genetic factors are unrelated to the major histocompatibility locus (AgB) of the rats. BN macrophages, although not active against tumor and/or viral antigens, can become cytotoxic to cells displaying Le alloantigens.

πŸ“œ SIMILAR VOLUMES

Macrophage-mediated tumor cytotoxicity:
Macrophage-mediated tumor cytotoxicity: Role of macrophage surface sialic acid
✍ Deborah J. Cameron πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 402 KB

## Abstract Cell surface sialic acid levels were compared for monocytes and macrophages obtained from normal volunteers and breast cancer patients. Equal quantities of sialic acid were found on the monoscytes obtained from normal volunteers and breast cancer patients. Approximately 60% more cell su

Non-T-cell-mediated cytotoxicity in MSV
Non-T-cell-mediated cytotoxicity in MSV tumor-bearing mice. III. Macrophage-mediated cytotoxicity against autochthonous MSV tumor-isolated target cells
✍ Dr. Susanne Becker; Stephen Haskill πŸ“‚ Article πŸ“… 1980 πŸ› John Wiley and Sons 🌐 French βš– 606 KB

## Abstract Cytotoxic macrophages have been isolated Moloney sarcoma virus (MSV) tumors induced in uncompromised, immunosuppressed and athymic nude mice. Macrophages from compromised mice were least as active as those from uncompromised mice when tested against the autochthonous MSV target cells. A

Antibody-dependent cellular cytotoxicity
Antibody-dependent cellular cytotoxicity against tumor cells. I. Cultivated bone marrow-derived macrophages kill tumor targets
✍ Marie-Luise Lohmann-Matthes; Wolfgang Domzig; Hristo Taskov πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 595 KB

## Abstract Mouse bone marrow cells are cultivated in a liquid culture system in the presence of fibroblast conditioned medium. Under these conditions, proliferation of macrophage and granulocyte precursor cells is induced. Cells of a 5‐day‐old culture are shown to act as cytotoxic effector cells a

Cytotoxic t-cell precursors against non-
Cytotoxic t-cell precursors against non-immunogenic rat tumors: Limiting dilution analysis
✍ M. ZΓΆller πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 French βš– 607 KB

After in vitro stimulation of lymphocytes with syngeneic tumor cells in the presence of interleukin 2 (IL-2). a cytotoxic T-cell response was observed against these spontaneously arising BDX tumors, which are non-immunogenic in the syngeneic host. The response was due to cytotoxic T-cells (CTL), whi