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Induction or elimination of tumor-specific immunity against a chemically-induced rat tumor using auto-anti-idiotypic immunity

✍ Scribed by Hans Binz; Beat Meier; Hans Wigzell

Book ID
102868133
Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
793 KB
Volume
29
Category
Article
ISSN
0020-7136

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✦ Synopsis

D A rat sarcomas PI and P, were induced by dimethylbenz (a) anthracene. A tumor-specific immune response of D A rats against P,-turnor cells could be demonstrated at the humoral and cellular level. D A anti-PI antibodies were purified on fixed PI-tumor cells and used as auto- immunogen in D A rats for the production of anti-idiotypic antibodies. Such anti-idiotypic antibodies could be demonstrated by using a solid-phase radioirnmunoassay and by their ability to induce secondary type of DA anti-P, responses in vitro. In addition, such antibodies were able to induce cytotoxic T lymphocytes capable of eliminating P,-tumor cells but not control tumor cells. In some of the auto-immunized DA rats enhanced P,-tumor growth could be observed, indicating that the anti-idiotypic immune response had led to a selective ablation of idiotypic, potential anti-P, reactive T cells.

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