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Role of diacylglycerol induced by hypoxia in the regulation of HIF-1α activity

✍ Scribed by Elisa Temes; Silvia Martı́n-Puig; Julián Aragonés; David R Jones; Gemma Olmos; Isabel Mérida; Manuel O Landázuri

Book ID
116287896
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
262 KB
Volume
315
Category
Article
ISSN
0006-291X

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## Abstract Oxygen‐dependent regulation of HIF‐1 activity occurs at multiple levels in vivo. The mechanisms regulating HIF‐1α protein expression have been most extensively analyzed but the ones modulating HIF‐1 transcriptional activity remain unclear. Changes in the phosphorylation and/or redox sta