Regulation of HIF prolyl hydroxylases by
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Olga Aprelikova; Gadisetti V.R. Chandramouli; Matthew Wood; James R. Vasselli; J
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Article
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2004
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John Wiley and Sons
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English
β 322 KB
## Abstract Hypoxia and induction of hypoxiaβinducible factors (HIFβ1Ξ± and HIFβ2Ξ±) is a hallmark of many tumors. Under normal oxygen tension HIFβalpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von HippelβLindau (VHL) tumor suppressor protein, a componen