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Hypoxia-induced activation of HIF-1: role of HIF-1α-Hsp90 interaction

✍ Scribed by E Minet; D Mottet; G Michel; I Roland; M Raes; J Remacle; C Michiels

Book ID: 117111597
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 638 KB
Volume: 460
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(99)01359-9

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## Abstract Oxygen‐dependent regulation of HIF‐1 activity occurs at multiple levels in vivo. The mechanisms regulating HIF‐1α protein expression have been most extensively analyzed but the ones modulating HIF‐1 transcriptional activity remain unclear. Changes in the phosphorylation and/or redox sta