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Zinc Induces the Accumulation of Hypoxia-Inducible Factor (HIF)-1α, but Inhibits the Nuclear Translocation of HIF-1β, Causing HIF-1 Inactivation

✍ Scribed by Chun, Yang Sook (author);Choi, Eunjoo (author);Kim, Gi Tae (author);Lee, Min Jae (author);Lee, Min Joung (author);Lee, Sang Eun (author);Kim, Myung Suk (author);Park, Jong Wan (author)

Book ID
115585273
Publisher
Academic Press Inc.
Year
2000
Tongue
English
Weight
118 KB
Volume
268
Category
Article
ISSN
0006-291X

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✍ Dae-Hee Lee; Yong J. Lee 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB

## Abstract Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells and induce the accumulation of hypoxia‐inducible factor‐1α (HIF‐1α) in normoxia. In this study, under hypoxic conditions (1% O~2~), we examined the effect of quercetin on the i