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Role of cyclooxygenase-2 in the angiogenesis of colorectal cancer

✍ Scribed by Milind Rao; Wenxuan Yang; AlexanderM. Seifalian; MarcC. Winslet

Publisher
Springer
Year
2004
Tongue
English
Weight
229 KB
Volume
19
Category
Article
ISSN
0179-1958

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## Abstract Cyclooxygenase‐2 (COX‐2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A causal link for COX‐2 in epithelial tumorigenesis was shown in genetically manipulated animal models of colon and bre