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Cyclooxygenase-2 and its role in colorectal cancer development

✍ Scribed by Dominique Wendum; Joëlle Masliah; Germain Trugnan; Jean-François Fléjou

Publisher
Springer
Year
2004
Tongue
English
Weight
238 KB
Volume
445
Category
Article
ISSN
1432-2307

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## Abstract Cyclooxygenase‐2 (COX‐2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A causal link for COX‐2 in epithelial tumorigenesis was shown in genetically manipulated animal models of colon and bre